Creatine 77

) it is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells of the body, especially the muscles. This is achieved by increasing the formation of adenosine triphosphate (ATP). Creatine was identified in 1832 when Michel Eugène Chevreul basified isolated skeletal muscle from extract of the water. Then he ordered the Greek word for flesh, κρέας (Kreas) the precipitated crystallized. Preliminary analysis showed that human blood is about 1% of creatine and higher concentrations found blood of an animal, brain (14%) and muscular 0 (50%) and 0 (0% 18) the testicles. Liver and kidneys contain about 0. 01% of the creatine. Today, the content of creatine (percentage of crude protein) can be used as an indicator of the quality of the meat. Occurs naturally in the body from the amino acids glycine and arginine. The first step in the biosynthesis of two amino acids are arginine combined: enzyme Amidinotransferase glycine (AGAT, CE: 2-4-1 (1), Guanidinoacetate, form and then it is methylated by Guanidinoacetate N-methyltransferase (TSAG, CE: 2)) 1-1 (2), with S-adenosyl-methionine as a methyl donor. Creatine itself can be phosphorylated in form of creatine kinase creatine 77 of Creatine phosphate, which is used as a reserve of energy in the skeletal muscle and brain. Synthesis is carried out mainly in the kidneys and liver, transported with creatine and then to the muscles through the bloodstream. Creatine is the skeletal muscle approximately 95% of the entire body. A study of vegetables and Nonveg 24 18 vegetarians on the effect of creatine among vegetarians that showed the total creatine significantly lower than the of non-vegetarians. As the plant is not the main source of creatine, derive vegetarian expected muscle under creatine show direct. However, those that occur at the same levels after using supplements to show. Because creatine above amino acids can be synthesized, these sources of proteins from amino acids is sufficient to provide adequate capacity for the biosynthesis of the native in the human body. Clinically, three different is there creatine metabolism disorders. Gaps of two synthetic enzymes can cause L-arginine: glycine Amidinotransferase deficiency and Guanidinoacetate Methyltransferase deficiency. The two biogenic defects are autosomal recessive inherited. A third party carries out, relationship SLC6A8 and creatine transporter deficiency mutations inherited x. This condition refers to the transport of creatine in the brain. Creatine is synthesized in the liver and kidneys, the blood performed and recorded by tissues with high energy, such as the brain and the requirements of the musculoskeletal, thanks to an active transport system. The ATP concentration in skeletal muscle tends to be mM, 2-5, causing a contraction of the muscle for a few seconds. Creatine supplements used by wrestlers, bodybuilders, athletes, sprinter and want to win another muscle mass. The clinic may says that creatine was the symptoms of asthma and warns the consumption of those with known allergies to the creatine. Discredited to ensure a systematic review of 2009, that creatine supplements can affect the State of grace and the heat of hydration and diarrhea and muscle cramps. Kidney damage reported to using creatine as interstitial nephritis; Patients with kidney failure should avoid the use of this supplement. As well as the function of the liver can be modified, and caution is advised in patients with underlying liver disease, although some studies have shown little or even nothing negative in the kidney or the liver of creatine supplementation by mouth. The management of large amounts of creatine is reported the production of formaldehyde, to increase, which has the potential to cause serious side effects. This risk is however largely theoretical, because the Elimination of formaldehyde, even under severe creatine supplements exceeds the normal limits. Extensive studies have shown that oral creatine supplementation of 5 to 20 grams per day appears to be very safe and largely free of side effects. Improve efficiency while at the same time, the physiological response to weight training reinforcement with maximum muscle force production of men and women. While some research suggests that pure creatine supplementation is safe a supplements available commercially survey 33 found that more than 50% of them exceed the recommendations of the European food security at least authority one contaminant. Creatinine was most of these contaminants, producing a breakdown product of creatine, also of the body. Creatinine was already in concentrations higher than the recommendations of the food safety authority European in 44% of the samples. Approximately 15% of the samples had detectable dihydro-1, 3, 5-triazine or a high concentration of Dicyandiamide. The contamination with heavy metals was a major concern, with only low levels of mercury detectable not found. Creatine serum or plasma endogenous concentrations in healthy adults is typically in the range of 2 to 12 mg/L. A single dose of 5 g (5000 mg) in healthy adults in the level of plasma concentrations peak creatine above 120 mg/L 1 or 2 hours. Creatine has a half-life elimination of relatively short, on average less than 3 hours and maintain high levels of plasma, you should take orally every 3-6 hours small doses over the course of the day. After loading dose period (1 - 2 weeks, 12 - 24 g/day), equals more necessary to high creatine serum. As with most supplements, each person their own genetic default, creatine can contain. The rest is excreted as waste. A typical dose is 2-5 g per day. From 2014, it is not clear if supplements have influence on the rate of cerebral palsy or other neurological problems during pregnancy. When mixing creatine with protein and sugar at high temperatures (above 148 ° C), the resulting reaction product heterocyclic amines (HCA). This reaction occurs when broiling meat or grilled bun Pan. HCA is known that cancer in animals to cause and can also cause cancer in humans. . . .